AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole)

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AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) Overview

• IUPAC Name: 1-[(5-fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone

• CAS Number: 335161-03-0

• Chemical Formula: C20H19FINO

• Molecular Weight: 435.27 g/mol

• ChemSpider ID: 8064843

Researchers who order AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) will find it particularly useful for receptor binding studies, ligand-receptor affinity models, and pharmacological assays.

Pharmacological Properties

• CB1 Receptor Affinity: Ki = 0.08 nM (very high binding potency)

• CB2 Receptor Affinity: Ki = 1.44 nM

• Selectivity: ~18-fold higher for CB1 over CB2

• Efficacy: EC50 = 52.8 nM | CB1 Emax = 63% (GTPγS binding assays)

The strong selectivity makes AM-694 an essential tool for researchers who buy AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) online for cannabinoid receptor studies.

Potential Laboratory Uses of AM-694

• Binding Affinity Testing: Crucial for CB1 receptor binding assays.

• In Vitro Vapor Diffusion: Useful in surface interaction studies with receptor-embedded membranes.

• Analytical Chemistry: Serves as a reference standard in GC/MS, FTIR, HPLC, and NMR.

• Metabolism Research: Helps study the breakdown of fluorinated cannabinoids and urinary metabolite identification.

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Safety & Handling

Due to its potency and psychoactive potential, AM-694 must be handled only by trained professionals in controlled laboratory settings. Always use protective equipment and follow proper storage protocols.

Summary Table

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